Platinum sensitive or not ?

[rosebine]

I wonder how they decide if you are platinum sensitive. I know its 6 months or under recurrence, but in my case after 5 months the cancer wasnt progressing, but when I was tested 2 months later it had progressed a lot, so it may have recurred at just over 5 monthsd,6 months or 7 ! However they have put me on a second line of carboplatin. It didnt actually do a lot the first time so Im not very positive about this lot.

[Hidden]

If you recur within 6 months you are considered platinum resistant

If you recur after 6 months you are considered platinum sensitive

I recurred after front line at 6 months, a registrar told me I was platinum resistant, my oncologist said I wasn't, and gave me carbo twice more, once with caylex and once with gemcitibine. I asked why I kept being prescribed carbo and the registrar said the drugs work better when combined.

[Newbie_2020]

Resistance is multi-factorial and it is far more complex that the categorisation of before or after 6 months. This is why some oncologists are challenging this and re-introducing carboplatin on a case by case basis.

Has your CA 125 been going down with the first treatment? at least you 'd know if you've had a biochemical response. Perhaps you have and this is why their judgement is to keep Carboplatin as a treatment?

If you don't feel confident with their decision, don't be upset about it and there is always a second opinion, as an option, to contemplate?

In my views, you have to have a clear state of mind about the treatment so you'd stay strong and keep the fight on.

[rosebine in reply to Newbie_2020]

It did go down for first line although shrinkage not much. CT after 4 treatments this time show very little change

[Newbie_2020 in reply to rosebine]

At times, after chemo, an increase in size or little or no change shown on CT scan could be due to possible cystic degeneration (dead cells) in ovarian masses.

Please ask these questions to your team and to the oncologists and let them explain to you the new plan of treatment and the rationale behind it.