So, we’re done with 7 Dose of chemotherapy, she is getting weak, and a lot of body pain. She is only 28 Years of Age.
Yesterday’s recent Scan (CA 125) also doesn’t shows any improvement, so it has gone up again from 17 to 90, it scares me a lot and as per doctors Chemo doesn’t works most of the time when it’s Low Grade Serous Carcinoma, I don’t know what to do now
Doctors are giving (injections) Bevetix 180 MG and Cisplatin 50 MG every week.
Please, if anyone has gone through similar situation then share your experience.
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prateek0490
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No experience of low grade but just wanted to say I am so sorry your wife is going through this and at such a young age. I hope they can find something that works to ward off this awful disease and gives her some relief from pain. Take care both of you. hugs, Kathy xx
So sorry about your wife. My mom is also stage III, low grade serous. Unfortunately in her case it is very extended through all the abdominal cavity, so it is not operable yet. She is having neoadjuvant chemotherapy (carboplatin, paclitaxel and bevacizumab), and after 3 cycles there was a small improvement but not enough for debulking surgery yet, so she will have at least 3 more and will be re-assesed after that. It is true that this cancer does not usually respond to chemo so the options are limited, but there are still a few therapies available. Has your wife been tested for hormone receptors? Many low-graders can benefit from hormonal therapy. Also, some mutations are more common in low graders, like MEK and BRAF, and that could be useful in the search for targeted therapies. I think the only good news is that this cancer is supposed to grow slowly, and that should give us more time. Just keep fighting! Hugs, Sara.
Hi I have stage 4 ppc, I am 36 and fighting this disease for the last 10 months, my original ca 125 on diagnoses was 1071 and it came down to 181 so never to normal levels I had a partial response to chemotherapy and i am on avastin until disease progression, has your wife had avastin or to the plan on adding it, its a biological therapy, I also take cbd paste and frankincense oil, I changed my diet to mainly organic and juice regularly and take wheatgrass shots I have lots of energy as I have 3 small kids. I found chemotherapy very tough and debilitating. My Ca 125s go up and down but never returned to normal. Im sorry to hear your wife is feeling so sick its not easy are they continuing with more chemotherapy. Hope things improve soon take care, Clare
Hello Prateek. I'm sorry she has seen no relief from treatment yet.
Are there any trials she could get into, e. g. for MEK inhibitors, as Seshat mentioned? Or maybe a second opinion could open up the option of surgery after all? Sending you hope and strength. Maus
Like the others, I feel very sad for your wife and for you.
I back what Maus says about a second opinion (made all the difference to my treatment and hence how I have lived since)...but also, you could talk with the Support Service Manager, Anna, at Ovacome on their freephone 0800 008 7054. Warm wishes, Lesley
I am so sorry you and wour wife are going through this. I read your previous posts, and from what I understand, she had surgery three months ago, but they left the lymph nodes, and it turned out that the cancer has spread to the lymph nodes as well? Have the doctors mentioned a second surgery as an option? I don’t know if they would do a second surgery so soon after the first one, but that should at least be an option in the future. Sending you both lots of strength. Kitty
I think a second opinion is a good idea. This made all the difference for me and got me on a clinical trial. If you are not already at a major cancer centre these are the best places to be seen- even f it involves a lot of travelling.
It is active and not recruiting but that is often subject to change as individuals move off trials for various reasons. It is also in the States but when trials are at the National Institutes of Health once you get to the States (just cross the border) and are in the trial they take care of all your expenses beyond the trial (flights and lodging). The trial is at the National Cancer Institute which is part of the National Institutes of Health so I think provide the same benefits.
Should also send you these two studies which are in the UK. Both are currently active and not recruiting but again talk to your oncologist as to when a space might be available. The first one is also sponsored by the NCI.
Should also mention that David Gershenson is the principal investigator in the first trial above and is also mentioned in the article I sent previously about Selumetinib Sulfate.
That is very hard to be going through this illness so young. I would see if you can get a second opinion anywhere near.
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