The use of low-dose naltrexone (LDN) for the treatment and prophylaxis of various bodily disorders is discussed. Accumulating evidence suggests that LDN can promote health supporting immune-modulation which may reduce various oncogenic and inflammatory autoimmune processes. Since LDN can upregulate endogenous opioid activity, it may also have a role in promoting stress resilience, exercise, social bonding, and emotional well-being, as well as amelioration of psychiatric problems such a autism and depression. It is proposed that LDN can be used effectively as a buffer for a large variety of bodily and mental ailments through its ability to beneficially modulate both the immune system and the brain neurochemistries that regulate positive affect.
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Julie8787
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That's interesting! I've just googled Naltrexone to learn more about it. There could well be some positive effects from it.
I'm a bit concerned about the way it dampens down opioid activity in the brain. That makes it useful for people who are addicted to opioids such as heroin. However, the brain does make its own opioids and they give us our feelings of well being, and I'd be afraid of damping down those as well. But I'm certainly interested to learn more about it.
I actually take a low dose of an anti-psychotic called aripiprazole which I've found helpful. It boosts the effects of the sertraline that I take for OCD, and helps with dopamine. It has made me feel more motivated and given me back something of my old self.
I should like to hear others' experience or thoughts on this too!
Hi Sally, Naltrexone is used at much higher dosages (over 50mg) to treat alcoholism and drug addiction. Low dose naltrexone genereally refers to under 5mg and has a very different effect on the body. Low Dose Naltrexone temporarily blocks opiate receptors in the body , for a few few hours. This tricks the brain into thinking it is deficient in endorphins and begins to stimulate endorphin production. When the blockade wears off, the body is flooded with all the beneficial endorphins it produced which remain in the body the rest of the day. Ive heard it could really help people that suffer from various mental or physical ailments due to a endorphin deficiency .. You can check out LDNscience.org or the LDN research trust to learn more
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