I have been taking Methotrexate for 5 months and Sulfasalazine for 5 weeks. I was diagnosed with RA in November last year after having symptoms, on and off, for 2 years. I have had 3 lots of steroids since then and my hands are not as painful every day as they were. I take Diclofenac modified release which I think is helping me more than anything else as well as Amitriptiline, Co-codamol and tramadol. I am now experiencing everything randomly as I was before it got severe last year. Pain and swelling moving from joint to joint and having one night per week when it is so unbearable I don't know what do do with myself and feel like I'm in hell!! My hands flare more than anywhere else but last night it was my knee and shoulder.....I couldn't walk this morning!! I feel very tired and depressed and am struggling to hold down my job, keep on top of the housework and be patient with my partner and 2 teenagers. HELP PLEASE!!