Elevated Vitamin A in serum with no supplements

[acousmetre]

Hi,

And sorry, this may not be the right place to post this, but in a recent blood test my serum vitamin A level was registered at 99.5mcg/dL with the lab's reference levels between 30 and 80mcg/dL. I've had vitamin A tested only once before in April last year and it too was high at 99.3. Does anyone know if this is a significant elevation?

I do not take vitamin supplements besides vitamin D , B and C, and that's really only on occasions (when my wife reminds me!).

Researching web, just about everything that I've found on hypervitaminosis A, points to excessive use of supplements. One "workup" description listed the need to rule out leukopenia, however.

Due to a recent surgery and a subsequent catheter-related UTI, I have not taken Golimumab for more than two months. I stopped taking MTX + folate over 3 months ago due to excessive fatigue.

My segmented leukocyte ratio was just above the lower reference at 42% on this test (ref 40-70). On the last, a month ago it was 33%. I imagine this is related to Golimunab/MTX.

My RBC is also slightly under reference range (4.5-6.10mil/mm3) at 4.44. and was 4.43 last month.

Might these haemogram results explain the Vitamin A? I have no clue...

In terms of Vitamin A toxicity symptoms - I've had abdominal pain , nausea, fatigue - but this is impossible to separate from my abdominal surgeries (4 in 2 years!) and also MTX. I have though had extremely dry eyes this year and consequently developed a cyst on one eye recently - fortunately it has gone with treatment.

The only other strange thing in my blood tests is a gradual rise in lipoprotein A since 2015. The level is meant to remain relatively static. Mine has raised from 51.9mg/dL to 90.5 since 2015 (ref. <30).

Other details - I had thyroid cancer in 2017 but this is thoroughly under control with no sign of return.

I will likely see the doctor that called for these tests at the end of next week or shortly after - but would be pleased if anyone here can offer suggestions about a possible cause of these Vit A levels..

Thanks!

[Hippo1234567]

I don’t know, but what I do know is that reference ranges are not absolute. It’s worked out on averages and some people will naturally be above and some below. We are all different and unique. Also you get different results as you age, some things go up and some things go down. Try not to worry too much, your doctor will be able to reassure you about your results

[acousmetre in reply to Hippo1234567]

Thanks. Not really worried, more curious. I like to have some background information before entering in a consultation. You may well be right about variation between individuals. I suspect it may be that too. Cheers