RA and immune system: Does taking methotrexate make... - NRAS

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RA and immune system


Does taking methotrexate make your immune system stronger or compromised?

6 Replies

Slightly compromised. But by controlling the disease apparently it does also make you less vulnerable.

Thanks helixhelix

Would that mean we have a compromised immunity with regard to the present Coronavirus?

in reply to josca1

By my understanding at least, if Mtx is the only thing you're taking then you may be slightly more at risk than the general population, but are unlikely to fall into the "high risk" category unless you're also taking other medications in addition and/or have other health conditions to take into account.

Also, as helixhelix has said, and also according to my understanding, uncontrolled RA is likely to put you at more risk than the (relatively?) marginal risk of taking the Mtx so in other words... it's probably best to keep popping those pills if/until your medical advisors tell you otherwise ;-)


Hi rheumatoid arthritis is caused by bodies immune response, most treatments cause suppression of the immune response.

Compromise most definitely

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