Not been on here for a while but i just wondered if anyone has experienced a problem with mtx. i find everytime i inject (monday evenings) I have a flare on the Wednesday, mainly my hands or wrists. How bizarre is that or is it just coincidence. i am currently on 20mg but the nausea is really getting to me to the point where i have called my RA nurses and said i cannot tolerate the nausea and fuzziness any longer, it really affects me in work for a good 24 hours after injecting. I have the folic acid and the anti sickness tabs but still struggling with it. Anyway giving it a break for 2 weeks and then going to go to Rheumy clinic to see what else i could go on. I did go through a remission stage for a few months but the flares are coming back quite regularly now with hardly a week where i don' have one or two flares. Is this the norm even when taking MTX or does my medication need looking at?.