Hi! I've recently been diagnosed with RA & have had severe symptoms for just over 6months. Im 31 & also have a sister with aggressive RA. Hereditary I guess. I'm about to take my first dose of MTX (pill 10mg) & I'm terrified. My sister begged me not to take it as it caused her liver problems. I've heard so many bad things about MTX but feel I need to give it a try. What doesn't work for my sister doesn't necessarily mean it won't work for me right? When is best to take MTX? And! How soon after taking do the side effects start?