Hi, I haven't posted before and started MTX last February when I joined. My 7.5 MTX was lowered to 4 but still had lethargy. I then got pneumonia and the RA doc did say that MRX may have caused it.( I later saw that people with a history of asthma are not good candidates) I'm reluctant to go to the next step--biologics. Any one have similar issues like this and ideas of where to turn? I also have Lyme that didn't respond completely with antibiotics but I treated it for 6 years and decided to treat the RA.