Hi All I wondered if anyone can tell me about ESR results and whether my GP is right to say that the raised inflammation might be the cause of my current extreme tiredness despite having only a little pain now. I feel that the MTX is working well with the joints but my ESR has only come down from 40 to 36 in two weeks. It was me who asked for these markers to be taken for first time in over 3 months since before I started the MTX. Ironically it was my GP who decided to take it today to see if it had gone down at all having told me that the practice don't take inflammatory markers once a patient has been diagnosed and treated for RA. I feel exhausted but not much pain at all now since my flare 2 weeks ago so I am a bit baffled by this although my GP thought the tiredness was just a hangover from the last very intense flare. Is 36 quite high still for someone who has been on MTX for over 3 months now do people know?