Hi everybody! I am new here and also quite new to RA. I was just diagnosed July 1, 2016. I had joint pain that moved around for 3 years but I just chalked it up to sleeping wrong or something, only because I'm 30 (this started when I was 27) and I didn't even know what RA was.
Well, the joint pain took a drastic turn in May and I was in constant horrible pain so I finally decided to see a doctor. At the same time, I developed peripheral neuropathy which is still spreading like wildfire, started as cold feet, turned into numb toes, and now my hands are always freezing and my skin burns everywhere. Ok, but back to the RA...
My rheumatoid factor was at 113 in May (probably higher now) and my anti-ccp was positive at 24 (apparently anything over 10 is positive?) also, elevated ESR and CRP, but Negative ANA. And of course I am iron deficient anemic. Anyway, rheumy started me on MTX. I have been on it for 2 months now and my RA is far better and I have little side effects. I just saw my rheumy last week and she ran some blood panels for Sjogren's and a few other autoimmune diseases that could result in neuropathy because she doesn't think the RA is causing it (no vasculitis)
Interestingly enough, my ANA is now positive at 1:320 (homogenous) but everything else was negative for Sjogrens, etc. My rheumy still doesn't know what is causing the neuropathy and is telling me the positive ANA "can be seen with RA" but when I google anything about it, all I see is that it's commonly associated with Lupus.
So, if you're all still reading this (sorry!!) I am just massively confused. Why would my ANA shift to positive now? I feel like something else is brewing. Does the positive anti-ccp absolutely confirm RA? It isn't possible I have Lupus and have been misdiagnosed with RA, is it? The only reason being I have read that neuropathy can happen with Lupus. But I honestly don't have the pain portion of Lupus. I don't have the dry eyes or dry mouth of Sjogrens. I'm not diabetic. I don't understand this neuropathy but it is worsening and it started when my RA reached a new level of terrible over the spring.
Does anybody have any light to shed or possible ideas here? I don't think I really understand what these blood tests mean and now I am just so depressed ever since my ANA shifted to positive because I can't find much of anything that confirms RA would result in a positive ANA.