Hi. This is my first post. I'm having a hard time finding information re: having a positive RF and positive anti-CCP with 21 inflamed joints 8 yrs ago, now being told both RF and anti-CCP are negative...maybe i don't have RA! Has this ever happened to anyone else? i'm having lots of joint pain, especially in ankles/feet, hands/wrists and more, but inflammatory markers are all neg (always have been) and no joint damage seen. I just had a bone scan that came back negative. My ANA titer is 1:160 and speckled, which can indicate Lupus, but my rheumy is not saying that. She said she doesn't know what is going on. Anyone out there have any advice?
Hi - I've had a slightly similar issue but not as dramatic. My rheumatoid factor was positive for the first year of my RA symptoms - but then, after two years on methotrexate -.it was down to equivocal and my RA symptoms have all but gone - only to be replaced by other connective tissue symptoms. However my anti CCP and ANA were both negative. I've been unable to tolerate four DMARDs to date so am just on a low dose of Prednisolone.
I have a new rheumatologist and am waiting to see what he comes up with, having had all my autoantibodies retested four years on from my diagnosis of RA. I'm expecting my diagnosis to switch to Undifferentiated Connective Tissue Disease. Unlike yours my inflammatory markers fluctuate in accordance with my pain but this on,y confirms autoimmunity - not which type.
My new rheumy has done all the testing again as well. everything negative except for the ANA, which again confirms autoimmunity, but not diagnostic, like you. Why Undifferentiated Connective tissue disease?
Hi Peggy - do you have any synovitis in your hands they could ultrasound?? Have you been on dmards and are you getting to stay on them?