My husband got diagnosed with RA in April of 2015, but was awaiting two knee replacements for osteo-arthritis in his knees, at the time. As he also has a chronically infected condition affecting his lungs, (bronchiectasis,) the local hospital didn't really want to do his knee replacements at all and at first tried to force him to just take strong DMARD drugs, stating these would improve his knees and make him able to walk again, (so far as we are aware DMARDS don't do anything for OA and my husband's RA in his other joints was mild.) We just thought the DMARDS would knock out his immune system and cause him even more serious chest infections, pneumonia or death and flatly refused. We found a local Orthopaedic Surgeon who was willing to replace my husband's knees under spinal block and both operations worked and his walking is better now than it has been in the last fifteen years. It has taken sometime to get both knees replaced and the swelling in my husband's hands has mostly gone. The Rheumatologist now says he doesn't have to take any DMARDS and can just have Hydroxychloroquine, or nothing, if he prefers. She says his ANA blood test is negative now. Does anyone know what an ANA test indicates please?