Hello everybody. I am new here. I was diagnosed with RA a couple of years ago. I can deal with the pain of RA pain. It is the extreme fatigue that I get periodically. I used to have episodes before I was diagnosed. Now almost every time I inject methotrexate I am sick and fatigued the next day or two. The fatigue is terrible. I either sleep or sit in my recliner until I recover. Has anybody experienced this? Is there an alternative to methotrexate? I am also on Remicade. I have had 4 infusion so far.