So it's been 14 months since diagnosis. 14 months of getting absolutely nowhere. Methotrexate made me unbelievably sick, sulpha didn't work, allergic reaction to rituximab and toxi(something or other by infusion I can't remember!!!!!!!!!!!) and now leflonamide is doing absolutely nothing! I have arthritis in every joint and it is just getting steadily worse. This last week I have been so fed up which just isn't like me but there just doesn't seem to be a light at the end of the tunnel. Anyone out there been in this position and can offer me some hope please?