There are a couple other posts on this topic here, but they are all pretty old, so I thought I'd start a new one. I'm a 40 yr old male. In general, I'm a very upbeat, sharp, intelligent, and active guy. I started taking Sulfasalazine (8 tabs per day) ~6 month ago for Colitis. When I first started taking it, the mood shift was pretty drastic, very high anxiety. I mentioned it to my doc and she was surprised, saying that she had never heard of such a reaction. Told me to keep on it and see how it went. After a couple more weeks, the crazy died down. However, ever since... I've just been off. My anxiety/depression (I don't really know which) has been pretty constant... there have even been a couple times where I've had what seems like a panic attack (I've never had one before, so I don't really know). These attributes are all very new to me and out of character. For months, I've just chalked it up to life circumstance... maybe it's a mid-life crisis, kids are teenagers now and more stressful, responsibilities at work have increased... blah blah blah. I've tried every "healthy" approach I can think of. I exercise regularly, eat right, have lots of friends, etc. But still this barrier remains. Truth is, I have an amazing life. I have a great job, am surrounded by love, had a great childhood, etc. But still there is "something" wrong. I can deal with anxiety. I often am able to resolve depression on my own. But what scares the sh$% out of me is that I just don't feel like myself. I feel hazy and cloudy... like my brain isn't firing on all cylinders. Making connections with people (which has come so easily to me) is getting really, really hard. I'm running out of options, out of new strategies to try... I'm starting to feel a little helpless. Then I found this site. Now I'm wondering if I'm one of the lucky, rare few who don't play nice with this med. A shame because it's doing a great job managing the Colitis and it's super cheap!
At any rate, I've just asked my doctor to switch my meds so I can experiment. I'm waiting to hear back. I'll let you know how that progresses. I'm just curious what other people's experience with Sulfasalazine has been?