I've seen a few older posts on this ... but wondering if anyone has any experience or knowledge about sulfasalazine and depression?
I have a history of depression / anxiety, but it's usually controlled okay. But I've been really struggling the last couple of months, with pretty intense paranoia and thoughts about dying. I saw the RA nurse this week and didn't want to admit how bad I've been feeling. I just said I'd had a low mood for the past few months, she was checking to see if hydroxychloroquine had any emotional effects as she didn't think it did but she knew sulfasalazine did.
But I wasn't depressed like I am now when I started hydroxychloroquine last year. It made me realise things have only got really bad since I started sulfasalazine. I've also really struggled with cognitive things. she said she'd see me in 6 weeks rather than 12, but if sulfasalazine is causing this I just want to stop it now. I can't keep having to work so hard to rationalise staying alive!
I've not noticed any improvements in pain/stiffness, but I understand it can take a while.
I don't understand the pharmacology of it though, how an RA drug can affect mood ...
Anyway, interested to know if anyone else has had psychological effects from this med.