Hi everyone, Is anyone on orencia and methotrexate? I am being switched from Enbrel to orencia and am a little frightened of this drug. It seems the older you are, taking this drug, the higher the chance of cancer. Any information or personal experience on this drug, will be very much appreciated. Also, have large bakers cysts behind both knees. Right one causeing a lot of leg pain. Any on have ant suggestions?