I have now received three loading doses of Abatacept (Orencia). This is a T cell inhibitor. I also seem to have developed a restricted artery in lower part of my heart. Consequently, the cardiologist added a drug to lower cholesterol and a drug which lowers blood pressure. I am very small and already have both low blood pressure and cholesterol. The inflammation has been under control since January. I feel AWEFULL. I have repeated headaches, back pain (extreme) and continued fatigue, joint pain and nausea. Is there any chance this drug will make a difference at this point ? I am trying to decide if I should risk discontinuing all drugs for a short period of time. This is the only way to know what is illness and what is side effects. My concern is with the bureaucracy involved in getting approval for the Biologics.