I have been on Leflunomide for 2 weeks. To start with I felt really tired but no other problems. Then yesterday morning my stomach felt a bit rough. It wore off, but today it has been bad all day. I haven't been able to eat properly and have nausea and feel weak and washed out. I rang the rheumy nurse who said leave taking it for a couple of days to see if symptoms go and then I'll know its the drug. I had stomach problems with sulphalazine and hydroxichloriquine. Methotrexate totally wiped me out with stomach, head, problems. I have been assessed for biologics and it looks like I will be ok to take them. I am scared about taking them and had really hoped I would be ok on methotrexate or leflunomide. It is a bit of a shock to find that I can't tolerate these drugs and I am scared that if I don't get on with Enbrel there isn't a lot left o try. My esr level was 50 back in December. I have had RA since 2008 and had low crp levels but it all changed last September. We had a nasty stomach bug. I know it probably sounds like an odd thing to ask but I was on a lot of NSAIDS over last summer and then had a steroid injection for carpal tunnel. I was then put on steroid tablets because of the high ESR and started methotrexate, I was then ill from the methotrexate and stopped it but was on a low dose steroid until March when I started to get a bad stomach and other side effects so they stopped the steroid. Now I have a bad stomach again. is it possible that although the drugs suppress the immune system and therefore should help the RA, if you get a lot of side effects which end up making your body weak then could that have the negative effect of adding to the problems with the immune system and actually making the RA worse? Any thoughts on any of my ramblings welcome. Take care all of you....... There is a web site called RA Warrior......that's what we are aren't we fighting this horrible disease. Maywing
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.