Hi my first time here. I am female aged 53 and have had RA since 1995 and had Sulphasalazine then after ten years went on to Methotrexate, then MTX 25mgs injectable and most recently since last year with added Lefuonimide tablets 10mg. I know this is not holding my RA much at all at the moment. My ESR is only kept down with hydrocortisone. I presently have several stiff swollen inflamed fingers and my knees can go immobile and huge with swollen tissue and have had the maximum of Kenalog injections to these joints in the past year. My Rheumatologist said last week they would like me to take a biologic to stop problems from getting out of control. I can have good periods of mobility especially after the shots, but I already have joint damage from early on with the RA as they could not diagnose me back in 1995. (I went almost a year with no meds as I didn't test positive for RA and during this time my hips and shoulder got erosion and my ankles damaged). I am very stressed at the thought of side effects and read that lymphoma and MS can be side effects of some if the biologics. I can't get this out of my head even though I know it is dangerous not to have the RA under control. Is there another drug on a similar level to MTX and Leflunomide which I could take instead? I understand my consultant wanting the best treatment for me but so far reading some articles for the biologics, all I can think of are those possible side effects. I have had an awful lot of stress lately which I always know contributes to my flare ups, and I feel stressed about the whole situation of changing drugs. Thanks for reading.