Have recently changed my medication for RLS from Pramipexole to Gabapentin as I felt that it was the Pramipexole that was not mixing well with my Methotrexate and making the nausea worse. However Gabapentin does not seem to be working for me at all and for the last few nights I have struggled to keep my legs under control and get some sleep. Tonight I have given in and am sitting here in my living room at 3am not having slept at all. Thought writing this might create a diversion for my brain and my legs and I think it might be working as they feel a little calmer. Will try to go back to bed and hope it will not start again as soon as I lie down. Methotrexate is annoyingly difficult to manage and I wish there was something more simple that would do the same job!!