Hi, I'm new to this site and was hoping that I could get some feed back about methotrexate injections vs oral methotrexate. I was diagnosed last April, I took leflunomide for a month but discontinued due to side effects and then started methotrexate in June with hydroxychloriquine and sulfasalazine added shortly after. Last week my hospital confirmed that I had met their criteria to officially prove that I have failed to respond to treatment and that I should now be put forward for the biologics. The problem is that my inflammatory markers are normal so I don't meet the criteria for the biologics. However I have been taking prednisolone daily since April, prior to this my esr was 30 and the pain in my hands, feet, knees and shoulders was such that I was struggling with daily activities. The hospital first suggested that I stop prednisolone completely, which I did yesterday and have already noticed an increase in pain, and wait for my inflammatory markers to increase or they're offering me methotrexate injections. Has anyone failed to respond to oral methotrexate but had improvements with the injections? Also on a separate note has anyone else been refused treatment and successfully appealed the decision? My consultant took my case to a hospital panel meeting but they have upheld the decision not to try me on biologics. I'd be really grateful for any feedback as I don't know anyone else with this condition to ask. Thanks
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