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Hi everyone,

Does anyone who is on Sulfasalazine suffer from constant sore throats?

I was on Methotrexate, Sulfasalazine & Hydrochloroquine

I took myself off Methotrexate back in February as I suffered from near 6 months with a sore throat & figured it was maybe the MTX lowering my immune system &therefore I was picking up throat virus' s. I went on a long term course of Antibiotics &it seemed to work for a bit but now its back again constantly. Im now considering that it is the Sulfasalazine. Does anyone have/has had a similar complaint?

Thanks for your time.

7 Replies

I've been on sulfa for around 2 years now, no side effects at all "yet" lol, can't help sorry.



I was on sulfasalazine for 12 weeks I had a rash, nausea, diarrhoea for 4 weeks and bed ridden for 2 weeks. it can affect people in different ways. i was put on methotrexate and hydrochloraquine after that and was great.



Yes the contraindications do include sore throat, mouth ulcers and sometimes cols sore type sores



I started on Sulfasalazine last week, taking 1 a day, yesterday im started on 2 a day, next week will start 3 a day then 4 a day week after, i woke up this morning with a terrible sore throat, dont know if it is the meds or not but i also cant sleep even with taking sleeping pills x


Hi, I have been on methotrexate for nearly 4 years now, and like you I experienced about 6 months of sore throats, swollen glands which always seemed to be only on one side of my throat! However I persevered and eventually they stopped. I get them rarely now. Good luck and happy new year for 2014


Thanks everyone for your replies. So calflo, you believe it was the MTX causing the problem....I did so at first but as its persisted 10 months after stopping it then this is why I started thinking it was the Sulfa. I had a really bad flare up after the MTX worked its way out of my system & have just got it under control with the help of steroids, but still have this poxy sore throat! Honestly, it is such hard work balancing out meds with side effects as well as one (or three!) Which is effective. I know you all understand this so thanks for your support! X


I've been on sulfasalazine for almost a year and have no sore throat but did have horribly chapped lips and a sloughing of my mouth. The doc put me on 4 mg of frolic acid per day and it all subsided. Good luck to you.


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