"In the United States, two of the phase 3 trials currently enrolling participants do not exclude people with CKD or kidney failure. However, solid organ transplant recipients are excluded because of the possible negative effect of anti-rejection therapy on mounting an immune response to a vaccine "
If your Transplant center has views - can you please share, no sooner I find my Post Transplant Care views.. I will post them
Thanks
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Lionkin
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This statement was published in September. A lot has changed since then, and we have now at least three vaccines to.choose from. Let's wait and see what the transplant community recommends as.the release date comes about. Keep safe and happy!
My transplant centre said that there is no issue in administering the vaccine, i have the flu jab and pneumonia ones already and it is the same re immunosuppression
My transplant center also said that a lot has changed since that statement was made. They recommended the vaccine to all transplant recipients. Every year I get the flu vaccine, this year the one for seniors and have had the pneumonia vaccines.My local nephrologist said I should be the first in line after the first responders for the vaccine.
I think you would want the vaccine rather than chance kidney and or lung failure and worse if you were to come down with COVID.
Talk it over with your nephrologist and ask his advice when they start to administer the vaccine in your area.
I am not disputing your team's claim, It's a matter of time for the truth to unfold, I am sure there are more finer details such as adequate density of T cells ... It is good to know that your team is on board with vaccine, My center is in the process of making a decision .. will let you know. As an example some of high level public health personnel - I saw a live interview with the Brown University Public Health Dean was asked the same question - He answered "there is not enough data for me to give you an assertive answer" Yes if you are 65 & above without a organ transplant - it is no brainer take the Vaccine.. no disagreements on that one.
KTR Covid seem to be impacting the weakest organ within the body such as Respiratory /heart / Kidney etc.
So Prior to the Vaccine - the inflammatory markers need to be checked to identify organ vulnerability
if you have a very low immune system , which translate into low density of T cells. T cells help in production of B cells which create antibodies. If you don't have a certain level of Covid antibodies you are susceptible to a Covid relapse.
Your assumption that vaccination can elicit powerful enough of an immune response to attack organs is incorrect.Furthermore, no current inflammatory biomarker is specific enough to diagnose individual "organ vulnerability".
Your concern about T and B cell density is theoretical in nature and in reality, transplant patients are on different types of immunosuppressive protocol of varying dose. It is not as black and white as it sounds. I don't know what to tell you except receiving vaccination against COVID is a no brainer to me and my colleagues.
Got my vaccine 10 hours ago. My team recommended the vaccine. I may have a weakened response to the vaccine because of the immunosuppressive medication. This is the same with any vaccine that transplant patients receive. I'll let you know if a get a response after the second dose. I believe some response from my immune system is better than none. I also prefer the risks of the vaccine vs the risk of COVID.
Congratulations & you can be a role model for all of us on the Covid Vaccine. I do have a couple of questions - you can choose to send me a direct reply too:
1, I am assuming it was a Pfizer Vaccine
2, After being vaccinated .. how much time elapsed before you went for Covid antibody verification test.
3, Prior to the vaccine- were your WBC, Neutrophils, Lymphocytes reading low, middle or high within the stipulated range.
Update on my end: My Transplant Center has vaccinated all the front line personnel who have had a transplant - and in 2 weeks time we will get an update.
Also in speaking one of the Transplant Director from New England area - it was stated that make sure the Post transplant team has a follow up protocol.
Finally I came across this Biontech article released yesterday - which alleviates some of the concerns as to how not to worry about some of the other viruses (CMV/BMV/EPV) present
Here is snippet:
All 37 participants vaccinated with BNT162b2 showed newly generated spike protein-specific CD4+ T cell responses, and almost 92% of participants demonstrated CD8+ T cell responses. The majority were strong T cell responses comparable to or significantly higher than memory responses of the same individuals against common viruses, such as cytomegalovirus (CMV), Epstein Barr virus (EBV) and the influenza virus. Even with the lowest dose of 1 µg BNT162b2, most of the vaccinated participants elicited robust expansion of CD4+ and CD8+ T cells. Expression of cytokines IFNγ and IL-2, but only low levels of IL-4 in BNT162b2-induced CD4+ T cells indicated a TH1 profile. CD8+ T cell responses were directed against multiple regions of the spike protein, and several of the multiple epitopes recognized by BNT162b2-induced CD8+ T cells were molecularly identified.
Just got my second Moderna shot 3 days ago. Both shots had no any side effects - essentially I did not feel anything except minor soreness in the arm.
I also had blood test just before my second shot (as requested by John Hopkins research I am participating in). Unfortunately antibody test came NEGATIVE. Per latest John Hopkins results only 17% of transplant recipients develop any traceable antibody after first shot. At this moment I do not have much hope for the second shot results either.
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Good Luck !
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