Just had my first infusion 3 days ago. It was a lot more straightforward and easier than anything I had read about Ocrevus.
Yes, the Benadryl shot made me drowsy for a few hours but given that I had to be locked on a chair for 5 hours, it was not a big deal.
No side effects, during the infusion or after and drove myself home alone after a bit of shopping (my husband was on call just in case).
I even think that the shot of steroid that comes with the procedure made me feel better by quieting down my hip pain (arthritis).
I have not set any expectations for the results. it will probably take until next MRI (6 months) before any difference is seen. Until then, I will keep exercising, eating right to keep the symptoms at bay (hopefully).