teardrop Rbcs following the use of medicine

[Violetaaa]

Hi everyone

A story has happened to me that has troubled my mind. I have been using interferon for about 4 years. At the beginning of using interferon, until we reached the desired dose, I became anemic after using a high dose, and small amounts of teardro RBC plus other abnormal shaped rbcs were observed in the blood slide(no abnormal rbcs befor that). As soon as we reduced the dose and started using it for 45mcg every two weeks , the anemia went away, the hemoglobin increased and abnormal RBCs were not seen. At the beginning of the diagnosis of my disease after i started using hydroxyurea, abnormal RBCs were also seen, but as soon as the dose was reduced, it returned to the normal(rbcs were completely normal on my initials blood test leading to ET diagnosis). I wanted to see if this happened to anyone else? In the meantime, I did a biopsy and no fibrosis was seen inside the bone marrow and diagnosis was ET but since then i‘ve been always concerned about those abnormal shaped rbcs

[MissLesley13]

Wow. I hope you get some answers soon. That sounds like you have a lot going on

[Violetaaa in reply to MissLesley13]

Thank u

Actually my hematologist told me abnormal shaped rbcs including teardrop shaped following the initial use of blood medicine such as hydroxy or interferon can be due to use of these medicines for first time with higher dose they can also cause temporary anemia which eliminates after adjusting dose So if no other signs and symptoms apear and these blood test findings are temporary no need to worry

Plus my bone marrow biopsy was fine and no fibrosis noted

Now I want to know if anyone had a similar experience