Don’t know if it’s true ….. : This is from a... - MPN Voice

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Don’t know if it’s true …..

lizzziep profile image
6 Replies

This is from a Facebook MF site. The person (in the USA I think) is saying a drug is being developed in Australia that will attack CALR and ASLX1 - I have no idea whether it is true, be great if it is.

Has anyone heard anything about this?

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lizzziep profile image
lizzziep
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6 Replies
hunter5582 profile image
hunter5582

This is the CALR peptide Based Vaccine trial for CALR that I know about.

classic.clinicaltrials.gov/...

Here is a bit more.

pubmed.ncbi.nlm.nih.gov/337...

mpncancerconnection.org/202...

Perhaps that is what is being referenced.

The short and very KISS explanation is that there is a difference in a protein found at the level of the cell wall with CALR mutated hematopoietic stem cells. This theoretically would allow the immune system to identify these mutated cells and target them for destruction. That is what this vaccine-based approach is about. Perhaps someone more up on this line of research can give a better explanation.

ainslie profile image
ainslie

I’ve heard a little about it, if it’s Dr Hoffman from New York he is a serious player to be taken seriously, best bear in mind it’s a trial though. You could ask Clair Harrison about it, she will probably know.

dbus1417 profile image
dbus1417

The antibody you’re referring to just entered clinical trials here in the US. My hematologist at MD Anderson says it will take some time (years?) to go through all the trials but that it looks promising.

Here is a pdf from the company that is developing it:

investor.incyte.com/node/22...

Pachena profile image
Pachena

This article was on an Australian Facebook group. It may be of interest -

theage.com.au/national/aust...

It is legit, the man in the video is in our group.

Phantasia profile image
Phantasia

Perhaps it's related to this:

abc.net.au/news/2022-03-25/...

Phantasia profile image
Phantasia

I have to say it looks as though Australia is punching above it's weight in the research stakes with MPNs.

Yay us!

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