Another fresh Rux trial, RuxoBeat

[EPguy]

This is a small phase 2b trial I've mentioned. It's at only 6 months, they plan to continue since it is getting good results.

link.springer.com/article/1...

I hope to study it deeper. What's new here is they did not require HU failure for HU pts to be in it. So these pts may in general be better responders.

One item of note is the allele result. The plot here is from the Bes trial, with the undisclosed 6 year result that I calculated and posted a while ago in orange. Gray is HU.

But relevant here is this study allows comparing the slope of the VAF reduction, and it's identical to IFN. From the other new studies we know this reduction on Rux continues on average, unlike with HU.

So the VAF benefit for Rux continues to look real and the other Rux trials are confirming for the 1st time a benefit to this reduction.

[Wyebird]

Am I right in thinking Ruxolitinib can be used for ET patients and doesn’t cause hair loss?

[ainslie in reply to Wyebird]

yes it can and if anything is good for hair, it’s also a treatment for certain types of alopecia in low doses

[EPguy in reply to Wyebird]

The study here included ET pts, but they have not analyzed that part so far here. Rux is most studied in MF, and PV is catching up. ET has fewer studies at this point.

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As ainslie says here, for the autoimmune condition alopecia areata.

"In this pilot study, 9 of 12 patients (75%) treated with ruxolitinib showed significant scalp hair regrowth and improvement of AA."

ncbi.nlm.nih.gov/pmc/articl...

Some reports I saw suggest it may get further study for other hair loss types. So it seems clear at least Rux won't cause more loss, and may add some back.

I did experience loss on HU and still it's a lot courser than it was even as I quit HU early last year.

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I'm hoping to get some of my life back with the autoimmune benefits of Rux.

[saltmarsh]

Many thanks for posting.