LDH Levels

[Zeppelin11]

I'm going on three weeks with Pegasys (90mcg once per week) and still taking two pills of Hydrea as well as an aspirin per day. My platelets continue to go down and are at 780,000 as if yesterday. However my LDH level is at 359 which is concerning me. Could this be a result of the two medications or my disease, or both? As far as side effects I'm just battling fatigue, some brain fog and I have slight discomfort in my pelvic area. Also realizing that if I don't stay really hydrated I'm basically a walking zombie. Hoping to just be on one medication soon.

[monarch5000]

It's rather routine for LDH to go up during the initial months of injecting interferon and then for it to trend downward and ultimately become normal if your disease is not real aggressive or advanced. Ditto in regards to liver enzyme test results.

[Zeppelin11 in reply to monarch5000]

Thank you for your reply. I have ET + CALR and I've been told I'm "low risk" as I do not have any family history of blood clots. So you would think I would just need to be on an aspirin regimen but my Platelets have other plans and need to be controlled with medication. Hoping Pegasys is a good fit

[K5Blazer86 in reply to Zeppelin11]

I am considered “low risk “ too .my platelets have bounced from over a million down to the lowest of 690,000. They had me taking Hydrea 1x each day ,but having 500ml of blood taken each week . I had not only high platelets,but both red and white cells, and HCT as high as 67.3(that is reasoning to blood draws ,they want mine 42 or less) . I also take aspirin. And because of side effects from Hydrea (burn like blisters in mouth ,down throat,and stomach burns and makes me sick ) I am on 2 meds for that . Hydrea is now every other day .

I got diagnosed 10/3/2022 with ET ,after further testing I do have the JAK2 V617F mutation.

I am 56 years old female ,(just turned 56 Jan 1st) .

My hematologist has been in touch with Mayo Clinic over my case ,which he says is very unusual. I am learning or trying to as much as I can . Hopefully you get the answers you are searching for .