I have ET and I've been to the hospital this morning and my platelets were down again to 385. The heam said I was heading for being normal - that's something I've always wanted to be and never succeeded at!!! I'm on 16 x 500mg HU per week, and an aspirin a day, I've been asked to continue at that dosage. So far, luckily, I have had few side effects, the excess acid has lessened now, my hairs a bit thinner and nails even weaker than they were before, the fuzzy head feeling is also lessening as I get more used to the tablets, it's a small price to pay for reducing the chance of a stroke or heart attack, although I know there are no guarantees! Although I do wish I could get some weight off, since being on the HU I just can't seem to lose it, I put some weight on as soon as I started on it. I go swimming 4 times a week and have cut out sweet things, but all to no avail. I guess my dreams of being a supermodel at the age of 60 are never to be fulfilled!!