Inflammatory response

[Eloise70]

J'AK2 mutation leads to increased platelet count and is linked to inflammatory response.'

I would like to know more on the symptoms related to inflammatory response.

Please direct me to this information?

I have had very itchy fingers last year, and have purple-coloured toes!! Is this an inflammatory symptom?

Thank you.

[hunter5582]

Generally itchiness is related to histamine release. Purple toes most like a microvascular issue. Regarding inflammatory response, it can vary and the answer is complex. The inflammation related conditions I experience include: GERD, eczema, osteoarthritis, tendonitis, insomnia. The Integrative Medicine doc I see confirms that systemic inflammation is something that is present and needs to be controlled.

My layman's version of looking at this is that the overproduction of inflammatory cytokines produces an environment in which a variety of inflammatory disorders are more likely to occur, It may not always cause the problem but can make the problem worse. in addition, the presence of inflammation causes reactive thrombocytosis. These processes are integrally linked,

Here are a few resources in which you may be interested,

ncbi.nlm.nih.gov/pmc/articl...

mpn-hub.com/medical-informa...

mpnlab.org/inflammation

youtube.com/watch?v=FzyoPAG...(Not working as expected?)

[Eloise70 in reply to hunter5582]

Many thanks for useful information, Hunter.

[EPguy]

Inflammation is increasingly recognized as important to many maladies:

"inflammatory processes are involved in not just a few select disorders, but a wide variety of mental and physical health problems that dominate present-day morbidity and mortality worldwide"

nature.com/articles/s41591-...

In MPN everything varies so much in our experience, including no symptoms at all.

I feel inflammation as malaise, it's a sense that the body is on fire and the head is filled with pressure. Some other members have described this sense, but it's impossible to understand if you've not had it.

The cytokines Hunter notes were a known cause of death in early Covid, luckily that is now rare. And MPN is not known to get this problem anywhere near that extent, more a simmering level for a longtime. But fewer of them is of course better.

Some supplements may help, although there is no proof of these. I and others here take NAC (N-acetylcysteine) or its related supplements, and Curcumin. I feel that NAC in particular helps to put out the fire.

[Aneliv9 in reply to EPguy]

Does your doctor agree with NAC supplements? Is there a possible side effect?

[EPguy in reply to Aneliv9]

My Dr agrees it's ok to take, he does not agree its known to be useful. He's right about that.

NAC for MPN is in an early clinical study. So we'll see at least a small sample of real info at some point soon. There are also some compelling animal studies.

Here is the NAC study:

clinicaltrials.gov/ct2/show...

It's generally considered safe even at high doses, but there is not much data on extended use. It is FDA approved and used at very high doses for paracetamol (tylenol) poisoning. But this is short term. It's considered generally protective for the liver, hence the paracetamol application. It can cause stinky stomach gas, but less so after longer use in my experience.

When you study the various inflammatory agents seen from MPN, NAC is active against them, one example is IL-6. Whether it actually helps in this way will be found in the clinical trials.

Curcumin is discussed in this post:

healthunlocked.com/mpnvoice...

No actual human trials, but promising.