“I think we’ll cure leukemia in my lifetime”

[Manouche]

“Is there anything else you’d like to share about leukemia treatment?

I'm very excited because I think we’ll cure leukemia in my lifetime. We’ve already come so far. For example, before 2000, patients with Philadelphia chromosome-positive acute lymphoblastic leukemia had a survival rate of 10%. Targeted therapy improved that to 35% to 40%, but patients had to receive a stem cell transplant, which isn’t easy. But I’ve led research on a drug called ponatinib in combination with chemotherapy, and we’ve seen the survival rate jump to 80% without a transplant. Our next goal is to increase the survival rate to 90% and eliminate the need for chemotherapy by using a combination of targeted therapy and immunotherapy.”

mdanderson.org/cancerwise/w...

[Superwoman]

Amazing news

[JediReject]

Hey Manouche, , Thanks for sharing this encouraging article with us , , I hope Doc is right and a cure isn't too long off. As a Stem Cell recipient I'd say "it isn't easy" is somewhat understated and the fewer folk that need it in future the better as it remains a bit of a lottery though ongoing research is improving outcomes. I know my case helped in some small way as I had severe Stage 4 GVHD and needed extensive after care to pull me through. I hope that we see these great strides transferring to curing MPNs for future generations.

Regards - Chris

[Manouche in reply to JediReject]

Hi Chris,

MPNs and leukemia’s cures will happen to OUR generation and not only to the future ones

“The latest method under investigation to attack leukemia is a bit like exterminating cockroaches: It’s a three-step process using cutting-edge technology to bait, trap, and kill leukemia cells at their root.”

urmc.rochester.edu/news/sto...

[mhos61 in reply to Manouche]

Thanks Manouche.

Hmm, mutant cockroach clone...🧐

In all seriousness though, very encouraging. All power to those great scientists, amazing brains!

[Aneliv9 in reply to Manouche]

Hello! It is very encouraging that i hear you say that MPNs and leukemia’s cures will happen to OUR generation. What are the signs that make you believe it?

[Manouche in reply to Aneliv9]

Hello Aneliv,

Hard to tell. Elias Jabbour, M.D. should be the right person to answer your question.

[Stevesmum42]

Thank you for posting. Very encouraging news.