New hope to cure patients with MPNs

[Manouche]

« Myeloproliferative neoplasms (MPNs) are a group of blood cancers that are maintained by stem cell populations. In this issue of JEM, Dagher et al. (doi.org/10.1084/jem.20201268) combine arsenic and interferon α to deliver a knockout punch to MPN stem cells and provide new hope to cure patients with MPNs. »

« Additionally, after IFNα+ATO treatment was withdrawn, primary mice were monitored for the reemergence of disease. In >50% of the IFNα+ATO combination–treated mice, the MPN did not recur after treatment was stopped, demonstrating long-term treatment-free remission and potentially a cure of the MPN. »

rupress.org/jem/article/218...

[ksos]

This is very interesting and hopeful. Thanks so much for posting it.

Kim

[littleluigi]

Isn't ATO very toxic? That may be a problem i guess..

[Manouche in reply to littleluigi]

« The Dose Makes the Poison

Nearly 500 years ago, Swiss physician and chemist Paracelsus expressed the basic principle of toxicology: “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” This is often condensed to: “The dose makes the poison.” It means that a substance that contains toxic properties can cause harm only if it occurs in a high enough concentration. »

chemicalsafetyfacts.org/dos...

[littleluigi in reply to Manouche]

If I understand. The dose is to low to make it very toxic? Sounds good

Will there be clinical trials? Is this not interesting for people like me who are in a very early disease to attack it now..

[Manouche in reply to littleluigi]

There will be trials very soon. The drug works already very well with some subtypes of myeloid leukemia ( daily IV injections for 100 days) and an oral form of ATO is being developed for MPNs. The oral drug is apparently much less cardiotoxic and liver toxic than the injectable one.

[jointpain in reply to Manouche]

How would one get on the trial for this potential cure?

[Manouche in reply to jointpain]

I’m not sure about the way to apply to a trial but I would suggest you to contact mpnvoice :

mpnvoice.org.uk/contact-us/

[Kiki64 in reply to Manouche]

Hi Manouche

This is a very interesting article.

Thank you

Kiki64

[Bluetop]

Both very positive. Thanks for posting!

[Meatloaf9]

Thank you for posting this very interesting and optimistic article. Lets hope and pray it works.

[rebeccaxxx]

Wow! Fingers crossed for some successful human trials then.

[Fizzydog]

Very interesting thank you for sharing it with us x

[Kiki64]

This is great news for us Manouche . Thanks for this post .

Kiki64 😊

[Snook37]

Thanks Manouche very interesting indeed