NEW HOPE FOR AML...

[socrates_8]

Post by MPN-MATE Admin » Wed Sep 25, 2019 2:05 am

Hey everyone...

This article is a tad tough to read through because of all the terminologies (jargon) used etc...

However, it is not all that difficult to follow the gist of these findings if one treats it more like an analogy of some mystery and suspense type story.

For example, in Myelofibrosis, Ruxolitinib (Jakafi) is used to suppress the 'Proliferation' of our blood cells, and hopefully thereby create some improvement in Quality of Life (QoL), and maybe even add a few years to our longevity (?) Jakafi therefore works as an Inhibitor (or Blocker) to the Signalling of mutant cells...

Essentially, this article, by a group of Japanese researchers doing the 'Detective' work by planning 'stake-outs' and tracking the movement of their subject groups, (the mutant proteins; inhibitors; chemical compounding treatments; and methods used in those applications), in an endeavour to provide a 'Cause & Effect' at the sub-atomic cellular levels. The Golgi apparatus, which is a transactional part, (organelle), of a cells anatomy:

"The Golgi apparatus, also called Golgi complex or Golgi body, is a membrane-bound organelle found in eukaryotic cells (cells with clearly defined nuclei) that is made up of a series of flattened stacked pouches called cisternae. It is located in the cytoplasm next to the endoplasmic reticulum and near the cell nucleus."

And it doesn't really matter that most of us don't know much about the Golgi at this stage, just that they are a part of a Leukaemic cell's structure. What is important is that we understand it is where much of the cells directions "Oncologic Signals" are coming from, (from those aberrant cellular mutations), and that this newly developed chemical compound, (M-COPA), might be helping to stem proliferation by 'Blocking' their signals to produce more of those aberrant cancer cells etc.

mpn-mate.com/forum/viewtopi...

Best wishes all

Steve

[Aneliv9]

Can you put it in simple words? I can't understand how "big" all this is

[socrates_8 in reply to Aneliv9]

Hey sure Aneliv...

In really simple terms; such a treatment for people with AML, might mean being able to have some hope of extended and better Quality of Life (QoL), life because of this treatment...

However, it is still all too early to really know much more at this point, and that is why I say –"Hope for AML etc"

Hope this helps...

Steve

[Aneliv9 in reply to socrates_8]

Thank you for the answer. Will this be the first treatment that extends survival beyond transplantation?

[socrates_8 in reply to Aneliv9]

Hi again...

I am sure that there have probably been other possibilities, however, I am not aware of what they might be? Sorry...

Aneliv, I am just an MPN patient too, and as such, I am just presenting articles that are related to our various MPN conditions.

However, I am not a doctor, or in any way a medically trained professional.

Hence, everything I present on the FORUM is for a news-worthy curiosity and content only...

Please do not rely upon my information as factual, as it simply comes from extracts from other people's articles and findings etc.

Hope this helps...

Steve

[Aneliv9 in reply to socrates_8]

I know don't worry!! Just hoping you knew

[socrates_8 in reply to Aneliv9]

Wish I did... wish somebody did!

Steve

[Innessant]

Thanks Steve.This means that as they understand the biology of the cells better they have a better idea of which chemicals/drugs can help block the blood cell ...machine. meaning we have the chance of more drugs coming down the road...and eventually, who knows, a cure within 10 years!!!

[socrates_8 in reply to Innessant]

Hey Innessant...

Absolutely, that is how I was viewing this article too...

As most of us are aware, having AML is a tough place to be, and so hope of something better might well be a wonderful thing for some...

And even more so, if that 10 years were to become say ... 5 or less...

I myself have MF, and the thought of not having many options if one was to progress, for me is a defeatist mindset, and that I would rather avoid at all costs...

Best wishes

Steve

[beetle]

Thank you for this and for putting it in simpler terms for us. I had actually heard of Golgi bodies but could not have told you what their function was to save my life! I find it exciting that the understanding of cellular biology is marching on at a pace. The glitch comes translating it all into functional medication which we all know takes time and money. Still without this kind of research no new drugs would appear so we all need to be thankful for it.

[socrates_8]

Exactly Beetle...

And where there is action, there too is hope... in my view...

Steve