Can clopidragel cause liver injury

[Spa1981]

I am 40 years old male. Recently I hv been diagnosed with pv and as i hv stomach injury so doctor gave me clopidragel 75 instead of aspirin along with periodic phlebotomy. I just wanted to know can clopid cause liver problem coz I am a chronic liver disease patient also. Looking forwad for insightful reply...

[Hidden]

products.sanofi.ca/en/plavi...

( always good to read the package inserts for all drugs) for Plavix, read clopidigrel.

Hepatic/Biliary/Pancreatic

Experience is limited in patients with moderate hepatic impairment who may have bleeding diatheses. As with any patient exhibiting hepatic impairment, liver function should be carefully monitored and PLAVIX should be used with caution.

In the CAPRIE study, there were 344 hepatically impaired patients (Alkaline phosphatase >300 U/L, or ALT >120 U/L, or AST >75 U/L) and 168 received clopidogrel for a mean duration of 18 months. The adverse events were more common in this population, compared to the rest of the CAPRIE population, and more common in the clopidogrel (N=168) than in the ASA (N=176) group (any bleeding disorders, N=17 vs N=14; any rash, N=11 vs N=6; diarrhea, N=8 vs N=3, respectively).

[hunter5582]

Most of the sources do not list issues with the liver due to clopidogrel. However, there are some reports of more rare issues with tolerance in the literature. ncbi.nlm.nih.gov/books/NBK5....

Do note this is a rare occurrence. As with all meds, you have to weigh the risks vs the benefits and compare to the other options. Certainly closely monitoring liver response will be important. Collaboration between your hematologist and the rest of your treatment team is also very important.