Just had my appendix out and Doctors don't want to give too many pain meds so have told be to take ibuprofen in between doses of percocet (has acetaminophen in it) to stretch them out. I thought there was a reason not to take ibuprofen when on hydroxyurea but not finding any contraindications. Does anyone have any information that can help me.
Thanks for any help and ouch, this hurts.
Hi H2ogal, hope you are ok and feeling a bit better, aspirin can interact with Ibuprofen, I can't see anything in the booklet about Hydroxyurea and Ibuprofen, but it is always best to check with your doctor or your pharmacy about any interactions. Hope your recovery is swift. Best wishes, Maz
My doctor prescribed ibuprofen for arthritis pain and I am also on Hydroxy. He told me it was fine as long as my platelets don’t go too low as it can cause bleeding. Suggest you talk to your doctor. Good luck with your recovery.
Hi. Hope you mend soon. My doc won’t let me take it as it affects how thin our blood is & I’m on blood thinner & baby aspirin. Good luck!! Katie
If like most MPNers you’re on aspirin then that’s the reason not to take ibuprofen. Haven’t come across any interaction with Hydroxy but as always worth double checking. Hope you are fully recovered very soon. Wishing you well.
Hi
My doctor told me not to take ibuprofen as it is a blood thinner and I am on Hydroxy. I would recommend checking with your haematologist.
Best wishes
Hope you'll soon feel lots better-
I have ET (reading is over 700) and was told to stay off Ibuprofen!
I am on Anagrelide x 2 daily and aspirin.
Wishing you good health!
My 'go to’ for information on drug interactions is always Medscape Drug Interaction Checker. That tells me that ibuprofen and hydroxycarbamide is not a problem but that all changes if you put aspirin in too! Hope that helps
As a further rider to my previous comment .... Given the discomfort you are in you might want to double check with the Haem if a) you can forgo the aspirin for a few days and b) take the ibuprofen instead. It’s not unusual (on advice) to stop aspirin for a number of days in order to take other meds - for example meds to relieve heavy / painful periods.
Ibuprofen and HU do not have a contraindication per ePocrates interaction check. As others noted, aspirin would be the issue. Here is the list of interactions based on the list you gave (assuming you do take aspirin).
ibuprofen (generic) + St. Joseph Low Dose Aspirin (aspirin)
Avoid/Use Alternative
ibuprofen + aspirin
avoid aspirin >325 mg/day; otherwise, monitor bleeding s/sx; give ibuprofen dose >400 mg 8h before or at least 2-4h after low-dose aspirin ER: combo may incr. risk of GI ulceration, perforation, other bleeding (incl. life-threatening), other adverse effects; ibuprofen may inhibit cardioprotective effect of low-dose aspirin (additive effects; possible competition for platelet binding sites)
Monitor/Modify Tx
ibuprofen (generic) + Percocet (oxycodone/ acetaminophen)
Monitor/Modify Tx
ibuprofen + acetaminophen
monitor renal fxn, especially w/ long-term concomitant tx: combo may incr. risk of nephrotoxicity (additive effects)
Percocet (oxycodone/ acetaminophen) + St. Joseph Low Dose Aspirin (aspirin)
Monitor/Modify Tx
acetaminophen + aspirin
monitor renal fxn, especially w/ long-term concomitant tx: combo may incr. risk of nephrotoxicity (additive effects)
Do be sure to review with your medical care team. You are wise in being careful with the Percocet. Opioids are sometimes needed, but not a good thing to take for extended periods of time. Addictive and loaded with unpleasant side-effects. I opted for acetaminophen-only after my last two surgeries.
Hope all goes well.
Thank you for the information & well wishes. I went without the pain medication for 2 hours so I could drive to pick up new prescription and wound up on my hands & knees sobbing in the parking lot because of the pain. Thought I was tougher than this. I'm an idiot for even trying to do that. Not needing the pain medication is my goal.
Sorry to hear you are having such a rough go of it. With that kind of pain, I can understand why opioids are warranted. There are a few things about opioids that you may find helpful.
1. Long-term use can require assistance with coming off the medication due to dependence. For some, dependence can occur in just a few weeks. There is a protocol that can be followed to ease this process of discontinuing opioids.
2. Some docs prefer to use Tramadol over the other options as is is seen as safer for some people (not all docs think this).
3. Expect you already know how Percocet affects your GI system. Stops me up like a cork. Movantik helps with this.
4. Long-term use can lead to hyperalgesia. You are very wise to try to limit your use to the minimum necessary to minimize this risk.
I hope your pain levels decrease and you can ease off the opioids as you want to be able to do. All the best to you. You will be in thoughts and prayers.
Thank you so very much
I'm just starting and have joint pain. Is that the pain you described?
My pain was from having my appendix out, but many people get joint pain when on hydroxy. I found that exercising in the water helped immensely. Just walking around in water or taking a water class made my joints feel better. Can't wait for Covid to end to get back in the pool. Hoped this helped.
I know if your on an aspirin and HU For MPN you cannot take ibuprofen for risk of bleeding and should resort to Tylenol. I am allergic to codeine and dislike Tylenol so I have to use cannabinoids or meditation to help with pain. If I can add my 2 cents Percocet causes more dehydration and can become addictive I would seek an alternative for that if you can too.
HYDROXY ADVICE. 
Hydroxy
First Hydroxy 
