Mesa: It’s an exciting time in MPNs without a doubt. I would break it down into 2 advances. The first is in patients with ET and PV. At this meeting, there continues to be further updates on the important role of long-acting interferons. They are having a big impact and are probably superior to hydroxyurea in both the first- and second-line. At this meeting, we are seeing data on both thrombosis-free survival rates as well as the molecular impact in terms of its use.
In MF, I think we see a very robust set of therapies developing, including a robust group of JAK inhibitors that will complement each other in terms of their activity. Novel combinations are looking at different mechanisms of action, such as BET inhibition, TGF-beta inhibition, LSD1 inhibition, etc., as well as new drugs in development for use even as single-agents.
This is an exciting time with a lot of things in development. I think the parallel of events we are seeing in MDS with the oral hypomethylating agents and other agents will likely have benefit for patients with advanced MPNs as well.