Greater Understanding of PV, ET Drives Potential New Treatment Options

[Manouche]

“Continued high-impact research may soon foster the development of disease-modifying therapies for PV and ET and satisfy this need for the optimal management of patients with these MPNs,” they said.

Researchers are also determining how to best optimize current treatment options, including JAK inhibitors and interferons. According to the authors, there is a lack of evidence on disease course modification associated with frontline JAK inhibitor treatment. To build on this data, studies of combination therapy have been initiated.

For example, a phase 2 study of ruxolitinib in combination with pegylated interferon alfa 2a (PEG-IFN alfa-2a) found the regimen was well tolerated, decreased JAK2 V617F allelic burden and symptoms, and resulted in remission for 10 of the 32 patients with PV deemed “almost entirely” intolerant or refractory to PEG-IFN alfa-2a.

ajmc.com/view/greater-under...

[EmeraldA]

I love your posts!

[MPort]

I love your posts too. They give me hope. But I have to decode them. Is 2A the new interferon we don't have available yet? Did an earlier post of your indicate Rux was not well tolerated? I can't join the dots with different trial results so I guess I will just have to accept hope!

[Manouche in reply to MPort]

Hi Mport, the alpha2A is the « old » Pegasys. Rux is a great drug but Pegasys is considered to be the cleanest drug available on the market. Both are generally well tolerated but as you know, everybody is different

[light]

Hi there, thank you for posting this interesting study. This is HOPE FOR MANY. Wishing you well,

[Aneliv9]

I am very curious if your doctors are optimistics about possible disease modifying treatments or curing of ET/PV and MF? Or maybe i ask this question on new post??😀

[Manouche in reply to Aneliv9]

Oh yes they are.

“Our results lay the groundwork for IFNα+ATO-based curative approaches of MPN”

ncbi.nlm.nih.gov/pmc/articl...

[Aneliv9 in reply to Manouche]

Thanks for the link. This study was from last year, do you know.if there is available update?? Also this study talks about interferon + arsenic. The poisonous arsenic????