I have posted this link before but worth repeating for new members of this Board.
RG7388 is an existing drug used in Acute Leukaemia, hence has a track record.
My very rough and amateurish synopsis:
We all have a p53 gene which effectively fights cancer.
Some/all of us have another gene called MDM2 which is stimulated by our JAK2 mutation into suppressing the good work being done by p53.
RG7388 kicks MDM2’s ass!
This link explains it must better
We know that Peg/Inf can reduce the % JAK Allele Burden which presumably reduces the ability of MDM2 to downgrade p53. However we also know that something else going on, that reducing Allele Burden not enough.
RG7388 looks a very useful new bullet and can be used with good effect in combination with Peg.
Is this the Silver bullet we are all hoping for? Probably not but if it wipes out one of our most dangerous mutations, it’s great news. Phase 2 trials about to begin.