Been on a steady dose of Peg (90mcg x 2 weeks) now for about a year - it took a while to get here as I started out on 2x that dose and was doing great until liver got sensitive. Went off or 2 months (and all readings jumped immediately) and went back on gradually at 2-3 week intervals. Have been patient as has my MPN specialist. Just did an interim CBC/liver panel a couple of days ago and platelets now at 488...still a little outside "normal" range (450) but the best I have seen in a decade and well within my MPN doctor tolerance of 600 (I am ET Jak2+).
My WBC is right in the middle of normal which for me feels low 
as prior to cytoreduction it was always elevated (11.0 - 14.0). Good news also on liver as it continues to behave. All readings WNL with the exception of ALT which is right above the upper limit (almost within range).
Since I am tolerating Peg well (feel a little flu-ish second day after injection) - we are going to leave dosage where it is for now. See my MPN specialist again in August and we'll see where things stand. I am advocating for maintaining the current dose (assuming everything stays ok) until we check my allele burden again. Current plan is to probably check by end of year - after 18 months at steady dose. Hoping that the positive response on blood work translates into a reduction of allele burden (which was quite high for ET).
Molecular remission of MF which is being treated with PEG 
Question for MPN patients in Canada
New User Name (EPguy) and MPN as a Continuum
Besremi One Year Update
