Hello, this is my first time reading a forum. I am 31yr old with ET with a cal-retic mutation. Was diagnosed last year. Started Hydrea in October, recently increased to 1000mg daily since my last plt count was 1.5. I am so relieved to read that I'm not alone in the fatigue dept. I am a nurse an after a 12 hr shift I can barely have the energy to shower and change. I am also on aspirin BID. I am hoping my numbers will come down with the increase and I won't feel so exhausted all the time.