I have had PV diagnosed for some 7 years now. Late last year i came off the Fedratinib trial and was placed back on Anagrelide. My current dose of 4 mg per day (previously it was 2mg /day) holds the platelet count quite well around the 400 mark , but I now very regularly suffer heavy nose and prostate bleeds. Apparently i now have an acquired Von Willebrand Syndrome. (a bleeding disorder). It is quite distressing. It always happens at night and I spend hours bringing it under control. Has anyone else suffered with bleeding and what can be done about it?????