Experiences with

Anagrelide

Does anyone know much about Anagrelide as its one of my treatment options as well as hydrea met with consultant yesterday and these are options she gave me and some info to read the difference between the two I am drawn to the Anagrelide seems to be less side effects but again I know everyone is different

I worry that he might want to use anagrelide at some point, and I want to be ready to make a decision with info on this. I worry so much about this diagnosis and my health. Any input would be appreciated. Thank you.

Whats Anagrelide like? Any thoughts much appreciated

So I am talking with my Hematologist today, and I am not sure if I should ask for a switch to an anagrelide or stay on the HU. I've been at 1,000mg/day and that didn't work well for me. On the other hand, I am not sure I want to have more issues with bleeding.

I am on Anagrelide at the moment but will have to switch medication very soon.I am intolerant to Hydrea. There are two possiblities: or Jakafi (rux) or Besremi. I wonder what would be the best solution. The spleen is not enlarged.

We discussed changing my meds to Anagrelide but having read about all the side effects I am in a dilemma as to what to do. Has anyone out there changed from hydroxycarbamide to Anagrelide with success.

Now that I'm on Anagrelide (0.5mg twice a day) my platelets are in the 600,000's and I seem to tolerate it ok. However I deal with rapid heartbeats, headaches, fatigue, mood swings and dizziness. I know the benefits outweigh the side effects but it can be very defeating.

Goid evening, I visited a local hematologist this week, not my MPN specialist, due to non coverage and he suggested trying combo of Hydroxyurea and Anagrelide. Has anyone used this combination for treatment of ET?

I have successfully transitioned to Anagrelide in the last 10 weeks, a dose of 200mg a day is starting to work… my recent 4 week blood test results showed my platelet count has dropped 200 to 844 😃😃🙌 which I know is still high but if this rate continues I will be in the normal range in the next few

The result was that I had grade 2 bone marrow scarring and she took me off the Anagrelide and put me back on Hydroxycarbamide. However, she also suggested that I consider starting Peg- Interferon.

500 mg 2 capsules beside 5 Anagrelide daily ,,interferon is not available at my health provider , and I can’t take risk with Hydroxyurea because of my cancer history ..

I was planning on starting low dose Anagrelide, .5 mg 2x daily, after the month off HU. However, I am aware headache and palpitations can be an issue with it, I also have Paroxysmal AFib so I take a blood thinner.

With ET JAK2 diagnosed 11 years ago, I've been on Litalir, changed to Anagrelide 2 years ago and for the last 4 months on Rux.

Anagrelide is a potent cytoreductive agent available as a second-line treatment for patients with ET.26 However, reports of inducing bone marrow fibrosis should be taken into consideration.27 Alternatively, ruxolitinib is an attractive therapeutic option for symptomatic patients with PV.

Have been put on Anagrelide & 1 epotein injection per week to try & prevent further transfusions. Consultant explained this leaves me prone to thrombotic events, but I do take Apixiban. My ignorance makes me wonder what happens to white platelets in my body, without the help of hydroxy.

Is that also possible with Anagrelide? Has somebody has an experience, or are there studies about combining these two?

Hi mpners,A bit of help needed, a balanced opinion on anagrelide please. I've an appointment tomorrow to decide on next treatment and there's lots of info on interferon but not for anagrelide.

I was on anagrelide for the first two years, then peg for four years. The weakness started in 2020 at same time as a mild TIA and mild cardiac issue, and same time my allele burden was on the rise up to 50% at time weakness started.

It goes on to say if you were on HU or anagrelide you will follow a pre-specified dose-tapering schedule. Not sure if that means your dose of HU, Anagrelide, or the Interferon. My question is for people already taking this drug. What is your dosage and frequency of use?

In view of the toxicity of HU, I requested changing to Anagrelide (which here in Switzerland costs about 5 times the price of HU), as I'd heard that Anagrelide specifically targets platelets, and in my case it certainly did: they went down to 254!