Lupus Anticoagulant

[Suecon]

Hi. Further to my post a few days ago another test result has been added - PNP Ratio, again positive. Is this significant, too?

[Chanpreet_Walia LUPUS UK]

Hi Suecon,

Are you referring to the RNP (Ribosomal-P) antibody?

The following information has been taken from The Lupus Encyclopedia:

RNP antibodies are not very specific for any particular disease. They can appear in people who have SLE, rheumatoid arthritis, Raynaud’s phenomenon and scleroderma. It is most useful in diagnosing a systemic autoimmune disease called mixed connective tissue disease where it appears in high amounts. It does not fluctuate consistently with disease activity, and therefore is not helpful in following how SLE responds to therapy.

I hope this provides some clarity!

[Suecon in reply to Chanpreet_Walia]

Hi. No, it's PNP Ratio and is included in the lupus anticoagulant test

[Chanpreet_Walia LUPUS UK in reply to Suecon]

Hi Suecon, okay :).

Below, is information about the Platelet Neutralisation Procedure (PNP) from the Archives of Pathology’s website:

The platelet neutralization procedure depends on the comparison of the aPTT or lupus anticoagulant–sensitive aPTT of the patient's platelet-poor plasma to that of the patient's plasma mixed with a platelet membrane preparation. In this assay, platelet membrane is used as a source of phospholipids. If the specimen contains lupus anticoagulant, then the clotting time may be substantially shortened in the patient's platelet membrane–containing plasma compared with the patient's platelet-poor plasma. When the platelet neutralization procedure was compared with the hexagonal phase phospholipid screening test, the former gave lower rates of detection than did the latter.

Here is some information on lupus anticoagulant (LA) which I hope you find useful:

“This inaccurate and confusing name is given to the second test for APS. Lupus anticoagulant is in fact a double misnomer and is NOT a test for lupus and is not an anticoagulant. Unsurprisingly, many people assume they have lupus when they are told they have tested positive for the LA but this is not true – they are testing positive for the aPL associated with APS”. (aps-support.org.uk/about-ap... Antiphospholipid antibodies are present in about 30-50% of people with lupus.

[Suecon in reply to Chanpreet_Walia]

That is helpful, many thanks