my wife was first diagnosed with Fibromyalgia 7years ago and put on amitriptyline to assist her deep sleep and body repair, which was supposed to help ease muscle pain etc..
Within a year, she was diagnosed with Lupus, POTS (postural orthostatic tachycardia syndrome) Angina, Osteoporosis, she gained weight, had IBS, had to quit work.
Over the last 6 years she continued to gain weight, be issued more and more medication and then was being diagnosed more issues relating to weight gain.
It wasn't until 3 months ago that a GP, said she has classic drug induced weight gain and was confident it was the amitriptyline.
She stopped taking it and suffered horrific withdrawal symptoms for 8 weeks, but now is feeling a LOT better and has already lost 2 stone!
Upon researching amitriptyline, the side effects are horrific, (too many to mention) with people reporting links to heart arrhythmia, increased heart rate, POTS, and since they have stopped the meds, have lost the weight gained, their heart rates returning to near normaility.
In our experience this is a very nasty drug and wouldn't recommend it to anyone.
Just on a speculative note and something i will update this site on is the fact that in the majority of people they seem to be diagnosed with Fibromyalgia, are given amitriptyline and then go on to be diagnosed with Lupus.
Could amitriptyline be producing Drug induced Lupus readings in the blood tests?
Time will tell with my wife so i will update if their is any significant progress.