Hello. How long does it usually take a person to adjust to Methotrexate to where your side effects are not so bad? I've been on it for a month as an addition to my Plaquenel that I've been taking for over a year without good results. The first 2-3 days after taking Methotrexate I feel like I'm literally dying. I'm so weak I can hardly get out of bed, sit up, drink anything, or walk. I also feel like I'm about to have an asthma attack and my chest hurts, I develop a loose cough, and feel congested in my chest. After day 3 is over, all of these issues go away. I realize they must be side affects of the drug, but just wonder if they will improve or approximately how long it takes for them to improve. I've heard Methotrexate can really help many people, so I am no where near ready to give up on it. I've been miserable for over 2 years and desperately want my life back. Thank you in advance for any responses.