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Is methotrexate all its cracked up to be?

Hey guys

After 6 months of GP/hospital visits, tests, weight gain from steroids and all that jazz

My rhumey has finally allowed me to go on methotrexate

At first I was thinking that it would be a magical drug that would make all my luppie problems and pains go away but now I am not so sure.

I think I am going to take it on either Fridays or Saturdays and take the folic acid the following day after incase I have any side effects

Any tips for coping with this medication and what symptoms do you have?

6 Replies

Hi, there I know a similar question is on here and has some good replies to it. If you browse by category of medications and then you will see the question on methotrexate and it has 9 replies. That has got some good responses that may help you. Hope things go well x


been taking methotrexate for around 3 years take on a thursday take a folic acid pill every day used to be a little woosie morning after till the first cup off coffee acording to the gp and reumy its working well i feel no side effects


Been taking Methotrexate for 2 years l take 7 on mondays and folic acid on fridays, luckily no side effects at all, it took a few months to work fully , but now the difference in my lupus has improved a lot, still get flare ups if l over do it, but it certainly help joint pain for me , hope it works for you, good luck.


Hi, I have been on methotrexate since January. I take it on a Wednesday and take folic acid twice a week - on a Monday and Friday. I found initially I had fatigue within 24/48 hours. It has taken months but I have seen an improvement in joint pain and get less burning malar rashes. I do still get flares if I over do it. I hope you have some luck with it too.


Hi-I have been taking methotrexate for 6 years. I take 8 on a Tuesday morning, and folic acid every day except for Tuesday. At first I really didn't feel good after taking them, but now I am fine with them, they are part of me, my disease and I wouldn't do without them,once in my system they made an incredible difference to my MCTD, RA and SLE. Hope it does the trick for you :-)


I have been on Methotrexate and folic acid for about 2 years now for my Lupus. I was told by my consultant to take the folic acid the day before you take Metho not the other way around. The Metho gave me terrible bowel problems for months when I started but was told this had nothing to do with the metho. also my hair started to get really thin on top so they doubled the folic and this seems to help. I take my metho near to a weekend in case of bowel probs.


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