Hi, I've just been told I have an ALK mutation. I'm stage 4 lung with mets to spine ,pelvis and liver. I'm waiting for a scan after three sessions of cisplatin and permetexed to see what's happening. My oncologist is looking at targeted therapies, does anyone have any success stories or have been on any of these drugs for some time? I think they are looking at crizitonib or Ceritinib? Are these any good? If the tumour shrinks enough can it become operable?