Experiences with

Ceritinib

So after 3 and half years Ceritinib has finally stopped working for me. It’s had a really good run but I always knew it wouldn’t be forever. I have been offered Lorlatinib as my next step in treatment.

New study [1]. "Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells" There have been 2 dozen CAPE papers these last 20 years. Ten of these specifically mention Akt inhibition. CAPE is found in propolis, which bees use to seal

I am stage 4 ALK positive and on treatment with Ceritinib for the last 3 years and was diagnosed over 5 years ago. I had SRS to 4 brain mets about 13 months ago. They responded really well with 2 disappearing,1 shrinking and one stable.

Doxazosin, an alpha1-adrenoceptor antagonist, is used for the treatment of benign prostatic hyperplasia (BPH) and hypertension. Alpha-adrenoceptor antagonists also inhibit growth and induce apoptosis in malignant prostatic cells. The apoptotic activity is independent of their capacity to antagonize

Hello I was just wondering if anyone has had a dose reduction from Ceritinib? I have been taking it successfully for 2 and a half years on the full dose of 450mg but have always struggled with gastric side effects.

My lung cancer is well controlled with targeted therapy, Ceritinib but they have just found 3 small tumours in my brain. I’m really frightened as I have read that the average survival with brain mets is 6 months. I’m only 47. Any experience with this would be much appreciated. Thanks x

I am stage 4 ALK+ and have been on Ceritinib for 2 years now which is working well. I have CT scans every 3 months to keep an eye on things and have always been told that my lungs are clear from tumours.

My wife has been on gefitinib for 3 years now for sclc doing fairly well a lot of side effects I just wanted to know if anybody was in the same drug did they weakness in the legs and coordination problems would appreciate some feedback thank you

I just wondered if there is anyone else out there who are now having to take Ceritinib as a film coated tablet? The capsule has been discontinued and initially I was very pleased as the tablet is much smaller than the capsule.

I am on targeted therapy Ceritinib which as far as I was aware is one of the protein kinase inhibitors which is on the government’s high risk list. I have had no text or letter advising me to stay home for 12 weeks and am worried that I have slipped through the net somehow.

The indication this new medicine will be assessed under is: "As monotherapy is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) whose disease has progressed after: Alectinib or ceritinib as the first ALK tyrosine

I was diagnosed with stage 4 lung cancer, metastasised on Xmas day last year and had no symptoms until I got breathless on Dec 16th. I'm 63. I've never smoked or drunk alcohol. I need oxygen regularly through the day. I have felt so isolated and angry since. I have not met anyone in my position at the

I am currently taking Ceritinib for stage 4 ALK positive lung cancer,my first 3 month scan showed a big reduction in size and quantity of tumours. My recent 6 month scan shows I have had a complete pathological response to the drug, which makes the dodgy side effects all worth it.

Hi everyone, I’m currently on the 450 mg dose of Ceritinib with food and have been for the last 4 months. I take mine in the morning but do suffer with stomach cramps, diarrhoea and nausea for several hours after.

Good article that provides an update - LOTS going on!! Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resistant Prostate Cancer Bryden Considine, DODaniel P. Petrylak, MD March 13, 2019 Volume: 33Issue: 3 Prostate

Hi all 😊 I am still around and check in on you all even if I don’t always post. As a lot of you know, my dad had stage IV NSCLC adenocarcinoma diagnosed 2/28/18, low tumor volume, and was held stable until 9/2018 at which time he went into the hospital on 10/16 and heartbreakingly passed on 11/20/18

Apparently my cancer has the ALK mutation so I am being prescribed Ceritinib, with a view to buying me more time with my family. I was advised this could amount to a number of years. Does anyone have any experience of taking this drug?

My wife is on gefitinib doing fairly well cancer stable but she has very bad itching in her arms any advice has used e45 not helping

Ceritinib was amazingly successful but pneumonitis meant we had to stop for now. Carb and Pem with 3 cycles of Pem but new brain secondaries. CT body today and Gamma Knife again as mets are symptomatic.

Diagnosed S4 with brain secondaries Feb 18 treated with Gamma Knife and ceritinib. Pneumonia so now just going onto Pem maintenance. Initial partial response now SD. ROS 1